Chronological List of References from the Science of Aging Timeline
(Click to see the expanded version)
- 1892
(01, January)
(01, January)
August Weismann Proposes a Difference Between Germ Line and Somatic Cells
- August Weismann. The Germ Plasm: A theory of heredity. Charles Scribners Sons, 1892.
- 1956
(1, July)
(1, July)
Denham Harman proposes the free radical theory of aging
- Harman, D. Aging: a theory based on free radical and radiation chemistry. J Gerontol. 1956 Jul;11(3):298-300.
- Harman, D. Aging: a theory based on free radical and radiation chemistry. J Gerontol. 1956 Jul;11(3):298-300.
- Florian L. Mullera, Michael S. Lustgartenb, Youngmok Janga, Arlan Richardsona,Holly Van Remmen. Trends in oxidative aging theories. Free Radical Biology and Medicine Volume 43, Issue 4, 15 August 2007, Pages 477-503
- Gruber J, Schaffer S, Halliwell B. The mitochondrial free radical theory of ageing--where do we stand? Front Biosci. 2008 May 1;13:6554-79.
- 1963
(15, February)
(15, February)
Leslie Orgel Proposes the "Error Catastrophe" Theory of Aging
- Orgel, LE. The maintenance of the accuracy of protein synthesis and its relevance to ageing. PNAS 49:517-21 (1963)
- 1965
(01, March)
(01, March)
Leonard Hayflick proposes the Cellular Theory of Aging based on the limited replicative lifespan of primary human cells
- Hayflick, L.. The limited in vitro lifetime of human diploid cell strains. 1965
- Campisi, J. Senescent Cells, Tumor Suppression, and Organismal Aging: Good Citizens, Bad Neighbors. 2005
- Hayflick, L.., Moorhead, P.S. The Serial Cultivation of Human Diploid Cell Strains. Experimental Cell Research, 1961, Dec;25:585-621.
- 1970
(19, September)
(19, September)
David and Harriet Gershon Find Accumulation of Non-active Enzymes in Older Nematodes
- H. Gershon, D. Gershon, Detection of Inactive Enzyme Molecules in Ageing Organisms. Nature 227, 1214-1217 (1970)
- 1983
(15, November)
(15, November)
Anthony Cerami proposes the Maillard Reaction theory of aging stating that DNA accumulates damage due to nonenzymatic modification from sugars
- R Bucala, P Model, A Cerami. Modification of DNA by reducing sugars: A possible mechanism for nucleic acid aging and age-related dysfunction in gene expression. PNAS, 1984.
- 1985
(01, December)
(01, December)
Carol W. Greider and Elizabeth H. Blackburn Discover A Specific Telomere Terminal
Transferase Later Known as Telomerase
- CW Greider, EH Blackburn. Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell. 1985 Dec;43(2 Pt 1):405-13
- Shampey, J., Szostak, J. W., and Blackburn, E. H. DNA sequences of telomeres maintained in yeast. Nature 310, 154-157, 1984
- 1988
(05, February)
(05, February)
Thomas Johnson and David Friedman Define the AGE-1 gene
- Friedman, D.B, Johnson, T.E. Three Mutants That Extend Both Mean and Maximum Life Span of the Nematode, Caenorhabditis elegans, Define the age-1 Gene. J. Gerontol. 43, B102-B109 (1988).
- 1994
(01, December)
(01, December)
Brian K. Kennedy et al. Discover that the Daughter Cells of Old Yeast have Shorter Life-Spans than those of Younger Strains
- Kennedy, B.K., Austriaco, N.R., Jr., and Guarente, L. (1994). Daughter cells of S. cerevisiae from old mothers display a reduced life span. J. Cell Biol., 137 1985-1993
- Guarente, L. Ageless Quest: One Scientists Search for Genes That Prolong Youth New York: Cold Spring Harbor Laboratory Press, 2003.
- 1997
(04, August)
(04, August)
Daniel E. Martěnez finds that Hydra do not show signs of Biological Aging
- Martinez, D.E. (May 1998), "Mortality patterns suggest lack of senescence in hydra.", Experimental Gerontology 33 (3): 217-225
- http://www.biology.pomona.edu/people/faculty/martinez.shtml
- 2003
(17, July)
(17, July)
Coleen Murphy et al. find genes downstream of daf-16 which regulate aging in C.elegans nematodes
- Coleen T. Murphy, Steven A. McCarroll, Cornelia I. Bargmann, Andrew Fraser, Ravi S. Kamath, Julie Ahringer, Hao Li, Cynthia Kenyon. Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature 424, 277-283 (17 July 2003) | doi:10.1038
- 2005
(18, November)
(18, November)
Matt Kaeberlein et al. propose that the TOR and Sch9 kinases regulate longevity in yeast
- Kaeberlein, M., Powers, R. W., 3rd, Steffen, K. K., Westman, E. A., Hu, D., Dang, N., Kerr, E. O., Kirkland, K. T., Fields, S., and Kennedy, B. K. (2005). Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. Science 310, 1193-1196.