Profiles in the Science of Aging
Below is a list of researchers in the biology of aging, describing their specific interests, methods, and giving links to their lab homepages.
Cynthia Kenyon at UCSFKeywords: daf-2,daf-16,C.elegans,bioinformatics
Dr. Cynthia Kenyon at the University of California San Francisco discovered that lifespan is regulated via the insulin growth factor pathway. Currently her lab focuses on discovering genes which act downstream of the IGF hormone, and further mechanisms which regulate aging.
Leonard Guarente at MITKeywords: sirtuins,Sir2,yeast
Dr. Leonard Guarente at the Massachusetts Institute of Technology discovered that lifespan is regulated in yeast via silent information regulators known as sirtuins or Sir 2. Currently his lab explores the role of Sir2 in mammals.
Coleen Murphy at PrincetonKeywords: daf-2,daf-16,C.elegans,bioinformatics
Dr. Coleen Murphy is an assistant professor at Princeton University where her lab employs microarray analysis to try find genes which regulate longevity in C. elegans nematodes. C. elegans have a lifespan of two to three weeks and thus are ideal model organisms for testing any candidate genes and their biochemical function.
Brian Kennedy at The University of WashingtonKeywords: Sir2,caloric restriction,yeast,mammals,genomics,bioinformatics
Brian Kennedy served as a graduate student in Leonard Guarente's lab where they discovered the role of Sir2 in regulating yeast aging. Kennedy works with the Consortium for the Determination of Public Pathways Regulating Longevity at the University of Washington. The work involves genome wide screens to find genes which regulate aging in yeast and find their conservation in eukaryotes such as worms and mice. Further, Kennedy is also reasearching the molecular pathways which extend lifepsan in calorie restricted yeast.
Matt Kaeberlein at The University of WashingtonKeywords: Sir2,caloric restriction,yeast,mammals,genomics,bioinformatics
Matt Kaeberlein served as a graduate student in Leonard Guarente's lab where he worked on the role of Sir2 in regulating yeast aging. Kaeberlein works in the Department of Pathology at the at the University of Washington and with the Consortium for the Determination of Public Pathways Regulating Longevity. His work involves genome wide screens to find genes which regulate aging in yeast and find their conservation in eukaryotes such as worms and mice. Further, Kaeberlein is also reasearching possible drug targets for Alzheimer's and Huntington's disease.
Andrea Bodnar at The Bermuda Institute of Ocean SciencesKeywords: telomerase,sea urchins,bioinformatics
Dr. Andrea Bodnar was employed at the Geron Corporation when she discovered the role of telomerase in extending the lifespan of cultured human cells. Bodnar currently works with the Bermuda Institute of Ocean Sciences, where she screens genomes of short and long lived search urchins to uncover genes which regulate aging.
Tomas Prolla at UW-MadisonKeywords: gene-expression
Tomas Prolla's Lab is currently focused on understanding the molecular basis of the aging process and common age-related human diseases through the use of large-scale gene expression analysis. They have recently characterized the gene expression profile of thousands of genes during the aging process of skeletal muscle and brain using “DNA-chips.”
Steven Artandi at StanfordKeywords: TERT,stem cells,telomeres
The Artandi lab is interested in understanding how stem cells self-renew and differentiate and how TERT (telomeres) modulate stem cell function.
David Harrison at The Jackson LaboratoryKeywords: IGF-1,stem cells
The Harrison lab at The Jackson Laboratory is interested in studying aging both from the IGF1 pathway and from the perspective of stem cells.
Hoa Li at UCSFKeywords: Pharmacogenomics, bioinformatics, yeast
The Li lab developes computational tools for genomic approaches to understanding the mechanisms of aging.
Are you a researcher in the science of aging who would like to be listed here? Please contact me.
For More Researchers See:
- The Ellison Medical Foundation's Listing for Researchers looking for Longevity Genes
- Grantees of the American Federation for Aging Research
Also, check out the links page.
